A systematic review of diabetic nephropathy associated polymorphisms and its genetic model

Norfazilah Ahmad, Mohd Rohaizat Hassan, Abdul Halim Abdul Ghafor, Azmawati Mohammed Nawi

Abstract

Different disease risk for diabetic nephropathy (DN) may be partly due to the diverse genetic susceptibility of the disease. This systematic review aimed to identify the genetic variants with a substantial effect on DN and to evaluate the genetic models used in the reviewed studies. We searched the ScienceDirect and PubMed databases for all eligible studies comparing genetic variants in patients with and without DN from 2005-2016. We included a total of 14 studies and identified 13 genes with 17 related variants. The OR was from 2.9 to 9.95. The genes were involved in the pathogenesis of DN via the hemodynamic (ACE, AGT, AGTR1), metabolic (ACACB, MTHFR, PPARGC1A) and inflammatory (TNF-a, TGFβ1, eNOS, CCR5, HSP70-1, MPO, OPN gene promoter) pathways. The results of these studies were presented according to pre-specified genetic models: basic, additive, dominant and recessive. No genetic model selection was biologically justified. We identified 17 genetic variants that were significantly associated with DN and were determined using different genetic models. To reduce error, further replication with the best genetic model should be carried out to determine the role of these variants in DN.

 


 Keywords:  case-control studies; diabetic nephropathy; genetic model; systematic review

 

 Cite as: Norfazilah Ahmad, Mohd Rohaizat Hassan, Abdul Halim Abdul Gafor, et al (2019) A systematic review of diabetic nephropathy associated polymorphisms and its genetic model. Asian Journal of Medicine and Biomedicine, Vol 3:1

 

Date received: February 14th, 2019      Date accepted:  April 18th, 2019

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