Interferences of Primary Cold Agglutinin with Pre-Transfusion Testing and Automated Peripheral Blood Cell Counting – A Case Report.

  • Salfarina Iberahim School of Medical Sciences, Universiti Sains Malaysia (USM), Kubang Kerian
  • Marne Abdullah
  • Noor Haslina Mohd Noor
  • Zefarina Zulkafli
  • Mohd Redzuan Abdullah
  • Afif Alam Faizli
  • Nurul Asyikin Nizam Akbar
  • Hany Haqimi Wan Hanafi
  • Faezahtul Arbaeyah Hussain

Abstract

Cold autoimmune hemolytic anaemia (AIHA) has several causes, including Primary Cold Agglutinin  (CAD). The cold AIHA in CAD is due to autoantibody anti-I. Most antibodies in cold AIHA are IgM subtype that optimally binds to red blood cells (RBCs) at 0°C–4°C. The presentation of the primary CAD is variable. Some patients presented with severe hemolytic anaemia and some incidentally had discrepancies in the laboratory results due to the cold agglutinin interferences. Here, we present a case of CAD secondary to clonal B Lymphoproliferative Disease (LPD). The patient presented with fever and had melaena. Upon blood taking for the investigations, the blood was easily clotted and his blood group showed discrepancy results forward and reverse.

Published
2024-02-28
How to Cite
Iberahim, S., Abdullah, M., Mohd Noor, N. H., Zulkafli, Z., Abdullah, M. R., Faizli, A. A., Nizam Akbar, N. A., Wan Hanafi, H. H., & Hussain, F. A. (2024). Interferences of Primary Cold Agglutinin with Pre-Transfusion Testing and Automated Peripheral Blood Cell Counting – A Case Report. Asian Journal of Medicine and Biomedicine, 8(1), 1-6. https://doi.org/10.37231/ajmb.2024.8.1.631