Challenges Confounding Biochemical Diagnosis of Acromegaly.

Biochemical Diagnosis of Acromegaly.

  • Mohd Zakwan Md Muslim Department of Chemical Pathology, Hospital Universiti Sains Malaysia, 16150 Kota Bharu, Malaysia https://orcid.org/0000-0003-2356-7846
  • Tuan Salwani Tuan Ismail Department of Chemical Pathology, Hospital Universiti Sains Malaysia, 16150 Kota Bharu, Malaysia http://orcid.org/0000-0002-7739-8323
  • Siti Nadirah Ab Rahim MBBS IIUM, MPATH (Chemical Pathology) USM Pathology Unit Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Perdana Sungai Besi 57000 Kuala Lumpur Orcid ID: 0000-0002-1878-0813 Email: nadirah@upnm.edu.my Office no. +60-390512498 https://orcid.org/0000-0002-1878-0813
  • Rahidatul Fairuz Ibrahim Hospital Pakar Sultanah Fatimah, Ministry of Health, Jalan Salleh 84000 Muar, Johor

Abstract

Abstract:

Acromegaly is a disorder caused by growth hormone (GH) hypersecretion resulting in excessive release of insulin like growth factor-1 (IGF-1). Both GH and IGF-1 measurements are crucial in its accurate diagnosis and in differentiating it from pseudoacromegaly. Early diagnosis is frequently restricted by its subtle, unnoticeable pathological changes; hence, clinical presentation is often late. Therefore, biochemical diagnosis is critical. However, the straightforward interpretation of these markers are hindered by factors that contribute to GH – IGF-1 discordance observed both in static and in dynamic function tests. These factors include both markers biological variation and their analytical assay limitations, which lead to false positive and negative results. This review is describing the pitfalls and challenges confounding the biochemical diagnosis of acromegaly. Despite these interpretive challenges, we strongly believe that interpretation of these results could be facilitated by effective clinician-laboratory professional communications which is the highlight of this review.

 

Keywords: Acromegaly, growth hormone (GH), insulin like growth factor-1 (IGF-1), IGF-binding proteins (IGFBP)

Author Biographies

Mohd Zakwan Md Muslim, Department of Chemical Pathology, Hospital Universiti Sains Malaysia, 16150 Kota Bharu, Malaysia

Trainee chemical pathologist

Tuan Salwani Tuan Ismail , Department of Chemical Pathology, Hospital Universiti Sains Malaysia, 16150 Kota Bharu, Malaysia

Consultant chemical pathologist

Siti Nadirah Ab Rahim, MBBS IIUM, MPATH (Chemical Pathology) USM Pathology Unit Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Perdana Sungai Besi 57000 Kuala Lumpur Orcid ID: 0000-0002-1878-0813 Email: nadirah@upnm.edu.my Office no. +60-390512498

Chemical Pathologist, Medical Lecturer

Rahidatul Fairuz Ibrahim, Hospital Pakar Sultanah Fatimah, Ministry of Health, Jalan Salleh 84000 Muar, Johor

Consultant chemical pathologist

Published
2024-02-28
How to Cite
Md Muslim, M. Z., Tuan Ismail , T. S., Ab Rahim, S. N., & Ibrahim, R. F. (2024). Challenges Confounding Biochemical Diagnosis of Acromegaly. Asian Journal of Medicine and Biomedicine, 8(1), 50-57. https://doi.org/10.37231/ajmb.2024.8.1.716