Tualang Honey Exerts Antidepressant-like Effects and Antioxidant Properties in Stress-exposed Rats
AbstractRecent evidence has exhibited dietary influence on the manifestation of depressive-like behaviour induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of depressive-like behaviour in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following groups: i) nonstressed with placebo, ii) nonstressed with honey, iii) stressed with placebo, and iv) stressed with honey. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressed rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Forced swimming test was performed to evaluate depressive-like behaviour. Stressed control rats displayed significant increase in depressive-like behaviour, serum adrenocorticotropic hormone (ACTH), corticosterone, and brain oxidative stress markers levels, with significant decrease in antioxidant enzymes activities and total antioxidant status. Honey supplementation successfully counteracted the stress effects whereby the honey treated rats exhibited significant decrease in depressive-like behaviour and levels of ACTH, corticosterone, and oxidative stress markers, with significant increase in antioxidant enzymes activities and total antioxidant status. In conclusion, Tualang honey mediated antidepressant-like effects in stressed rats, possibly acting via restoration of hypothalamic-pituitary-adrenal axis through its antioxidant properties.
Al-Mamary, M., Al-Meeri, A., & Al-Habori, M. (2002). Antioxidant activities and total phenolics of different types of honey. Nutrition Research, 22(9), 1041-1047.
Al-Rahbi, B., Zakaria, R., Othman, Z., Hassan, A., & Ahmad, A. (2013). Enhancement of brain BDNF concentration and restoration of the hypothalamic-pituitary-adrenal axis accompanies reduced depressive-like behaviour in stressed ovarectomised rats treated with either Tualang honey or estrogen. The Scientific World Journal.
Al-Rahbi, B., Zakaria, R., Othman, Z., Hassan, A., Ismail, Z. I. M., & Muthuraju, S. (2014). Tualang honey supplement improves memory performance and hippocampal morphology in stressed ovariectomized rats. Acta histochemica, 116(1), 79-88.
Aljadi, A., & Kamaruddin, M. (2004). Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys. Food Chemistry, 85(4), 513-518.
Anderson, P. A., Berzins, I. K., Fogarty, F., Hamlin, H. J., & Guillette Jr, L. J. (2011). Sound, stress, and seahorses: The consequences of a noisy environment to animal health. Aquaculture, 311(1–4), 129-138.
Azman, K. F., Zakaria, R., AbdAziz, C., Othman, Z., & Al-Rahbi, B. (2015). Tualang honey improves memory performance and decreases depressive-like behaviour in rats exposed to loud noise stress. Noise and Health, 17(75), 83.
Bakunina, N., Pariante, C. M., & Zunszain, P. A. (2015). Immune mechanisms linked to depression via oxidative stress and neuroprogression. Immunology, 144(3), 365-373.
Beretta, G., Orioli, M., & Facino, R. M. (2007). Antioxidant and radical scavenging activity of honey in endothelial cell cultures (EA. hy926). Planta Medica, 73(11), 1182-1189.
Bhatnagar, S., Vining, C., Iyer, V., & Kinni, V. (2006). Changes in hypothalamic-pituitary-adrenal function, body temperature, body weight and food intake with repeated social stress exposure in rats. Journal of Neuroendocrinology, 18(1), 13-24.
Bulduk, S., & Canbeyli, R. (2004). Effect of inescapable tones on behavioural despair in Wistar rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 28(3), 471-475.
Cheng, L., Wang, S.-H., Chen, Q.-C., & Liao, X.-M. (2011). Moderate noise induced cognition impairment of mice and its underlying mechanisms. Physiology & Behaviour, 104(5), 981-988.
Demirel, R., Mollaoğlu, H., Yeşilyurt, H., Üçok, K., Ayçiçek, A., & Akkaya, M. (2009). Noise induces oxidative stress in rat. European Journal of General Medicine, 6(1), 20-24.
Engelmann, M., Ebner, K., Landgraf, R., & Wotjak, C. T. (2006). Effects of Morris water maze testing on the neuroendocrine stress response and intrahypothalamic release of vasopressin and oxytocin in the rat. Hormones and Behaviour, 50(3), 496-501.
Erejuwa, O. O., Sulaiman, S. A., Wahab, M. S., Sirajudeen, K. N., Salleh, M. S., & Gurtu, S. (2010). Antioxidant protection of Malaysian Tualang honey in pancreas of normal and streptozotocin-induced diabetic rats. Annales d'endocrinologie (Paris), 71(4), 291-296.
Erejuwa, O. O., Sulaiman, S. A., Wahab, M. S. A., Salam, S. K. N., Salleh, M. S. M., & Gurtu, S. (2011). Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats. International Journal of Molecular Sciences, 12(1), 829-843.
Evans, G. W., Hygge, S., & Bullinger, M. (1995). Chronic noise and psychological stress. Psychological Science, 333-338.
Gheldof, N., & Engeseth, N. J. (2002). Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. Journal of Agricultural and Food Chemistry, 50(10), 3050-3055.
Heim, C., & Nemeroff, C. B. (1999). The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. Biological Psychiatry, 46(11), 1509-1522.
Holtzheimer, P. E., & Nemeroff, C. B. (2006). Advances in the treatment of depression. NeuroRX, 3(1), 42-56.
Ilhan, A., Gurel, A., Armutcu, F., Kamisli, S., Iraz, M., Akyol, O., et al. (2004). Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain. Clinica Chimica Acta, 340(1), 153-162.
Khalil, M., Alam, N., Moniruzzaman, M., Sulaiman, S., & Gan, S. (2011). Phenolic acid composition and antioxidant properties of Malaysian honeys. Journal of Food Science, 76(6), C921-C928.
Khalil, M. I., Mahaneem, M., Jamalullail, S., Alam, N., & Sulaiman, S. (2011). Evaluation of radical scavenging activity and colour intensity of nine Malaysian honeys of different origin. Journal of Api Product and Api Medical Science, 3(1), 4-11.
Kishore, R. K., Halim, A. S., Syazana, M., & Sirajudeen, K. (2011). Tualang honey has higher phenolic content and greater radical scavenging activity compared with other honey sources. Nutrition Research, 31(4), 322-325.
Krishnan, V., & Nestler, E. J. (2008). The molecular neurobiology of depression. Nature, 455, 894.
Lagunas, N., Calmarza-Font, I., Diz-Chaves, Y., & Garcia-Segura, L. M. (2010). Long-term ovariectomy enhances anxiety and depressive-like behaviours in mice submitted to chronic unpredictable stress. Hormones and Behaviour, 58(5), 786-791.
Lang, U. E., & Borgwardt, S. (2013). Molecular mechanisms of depression: Perspectives on new treatment strategies. Cellular Physiology and Biochemistry, 31(6), 761-777.
Lenzi, P., Frenzilli, G., Gesi, M., Ferrucci, M., Lazzeri, G., Fornai, F., et al. (2003). DNA damage associated with ultrastructural alterations in rat myocardium after loud noise exposure. Environmental health perspectives, 111(4), 467.
McEwen, B. S. (2000). Allostasis and allostatic load: Implications for neuropsychopharmacology. Neuropsychopharmacology, 22(2), 108-124.
Moniruzzaman, M., Khalil, M. I., Sulaiman, S. A., & Gan, S. H. (2013). Physicochemical and antioxidant properties of Malaysian honeys produced by Apis cerana, Apis dorsata and Apis mellifera. BMC Complementary and Alternative Medicine, 13(1), 43.
Naqvi, F., Haider, S., Batool, Z., Perveen, T., & Haleem, D. J. (2012). Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behaviour in rats. Pharmacological Reports, 64(1), 64-69.
Oliveira, M. J., Monteiro, M. P., Ribeiro, A. M., Pignatelli, D., & Aguas, A. P. (2009). Chronic exposure of rats to occupational textile noise causes cytological changes in adrenal cortex. Noise and Health, 11(43), 118-123.
Othman, Z., Shafin, N., Zakaria, R., Hussain, N. H. N., & Mohammad, W. M. Z. W. (2011). Improvement in immediate memory after 16 weeks of Tualang honey (Agro Mas) supplement in healthy postmenopausal women. Menopause, 18(11), 1219-1224.
Porsolt, R., Bertin, A., & Jalfre, M. (1977). Behavioural despair in mice: a primary screening test for antidepressants. Archives Internationales de Pharmacodynamie et de Thérapie, 229(2), 327-336.
Porsolt, R. D., Le Pichon, M., & Jalfre, M. (1977). Depression: a new animal model sensitive to antidepressant treatments. Nature, 266(5604), 730-732.
Ravindran, R., Devi, R. S., Samson, J., & Senthilvelan, M. (2005). Noise-stress-induced brain neurotransmitter changes and the effect of Ocimum sanctum (Linn) treatment in albino rats. Journal of Pharmacological Sciences, 98(4), 354-360.
Rocha, B. A., Fleischer, R., Schaeffer, J. M., Rohrer, S. P., & Hickey, G. J. (2005). 17b-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-b knockout (BERKO) mice. Psychopharmacology, 179(3), 637-643.
Sack, C. A., Socci, D. J., Crandall, B. M., & Arendash, G. W. (1996). Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats. Neuroscience Letters, 205(3), 181-184.
Samson, J., Sheeladevi, R., & Ravindran, R. (2007). Oxidative stress in brain and antioxidant activity of Ocimum sanctum in noise exposure. Neurotoxicology, 28(3), 679-685.
Shafin, N., Othman, Z., Zakaria, R., & Nik Hussain, N. H. (2014). Tualang honey supplementation reduces blood oxidative stress levels/activities in postmenopausal women. ISRN Oxidative Medicine, 2014.
Slattery, D. A., Desrayaud, S., & Cryan, J. F. (2005). GABAB receptor antagonist-mediated antidepressant-like behaviour is serotonin-dependent. Journal of Pharmacology and Experimental Therapeutics, 312(1), 290-296.
Souery, D., Papakostas, G. I., & Trivedi, M. H. (2006). Treatment-resistant depression. The Journal of Clinical Psychiatry, 67, 16-22.
Srikumar, R., Parthasarathy, N. J., Manikandan, S., Narayanan, G. S., & Sheeladevi, R. (2006). Effect of Triphala on oxidative stress and on cell-mediated immune response against noise stress in rats. Molecular and Cellular Biochemistry, 283(1-2), 67-74.
Yildirim, I., Kilinc, M., Okur, E., Inanc Tolun, F., Kilic, M. A., Kurutas, E. B., et al. (2007). The effects of noise on hearing and oxidative stress in textile workers. Industrial Health, 45(6), 743-749.