In Vitro Cytotoxicity and Antioxidant Activities of Pestalotiopsis microspora Culture Filtrate

  • Taofeeq Garuba University of Ilorin, Ilorin, Nigeria
  • Saheed Sabiu Kwara State University
  • Adebola Azeez Lateef University of Ilorin
  • Alimat Taiwo Adekanmbi University of Ilorin
  • Maryam Kehinde Adekanmbi University of Ilorin


Endophytic fungi have been studied to provide protection and survival conditions to their host plant by producing a plethora of substances which, once isolated and characterized, may also have potential for use in industry, agriculture, and medicine. In this study, the culture filtrate of an endophytic fungus (Pestalotiopsis microspora (PM)) was evaluated for its cytotoxic and antioxidant activities in vitro. The cytotoxic activity of PM was determined using brine shrimp lethality assay (BSLA), while its antioxidant effect was investigated against DPPH, reducing power and hydroxyl radicals. Judging by the LC50 value of 2.71 mgmL-1 for the BSLA, the culture filtrate could be considered highly potent. The PM also significantly scavenged free radicals and the effects elicited could be attributed to its phenolics and other phytoconstituents as revealed by the GC-MS results.  It is thereby evident from the data presented that PM is endowed with chemotherapeutic constituents that could be potentially useful for the development of new lead anticancer agents.

Author Biography

Taofeeq Garuba, University of Ilorin, Ilorin, Nigeria

Plant Biology Department, University of Ilorin, Ilorin, Nigeria.

Lecturer II


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How to Cite
Garuba, T., Sabiu, S., Lateef, A. A., Adekanmbi, A. T., & Adekanmbi, M. K. (2018). In Vitro Cytotoxicity and Antioxidant Activities of Pestalotiopsis microspora Culture Filtrate. Malaysian Journal of Applied Sciences, 3(1), 24-33. Retrieved from
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