Psoariasis Vrs Alstonia Scholaris: Computational Validation as Functional Food

Key Words : Psoriasis; Functional Food; TRPV3 ion channel; Alstonia scholaris; Alstolenine; Molecular docking; Clinical Observation; In-Silico study.

Abstract

Introduction : Psoriasis is a skin disease. It is rare & is expanding worldwide. In this investigation the ion channel protein TRPV3 (Transient receptor potential cation channel, subfamily III ) has been targeted vis-à-vis  psoriasis, which is a important factor.

Objective : To find out Alstonia scholaris’s  phyto compounds efficacy against psoriasis  and use as functional food.

Material and Methods : (i) The sun dried powder of the whole bark of medicinal plant Alstonia scholaris in capsule form @450mg/cap as ‘Functional Food’ in Fixed dose (ii) Two phytocompounds (Alstolenine and (-) Scholarine) were taken from the mature tree’s bark for In Silico investigation.

Results : (i) Functional Food use as was administered and results recorded indicate near clear results with no toxicity. In-Silico molecular docking indicates Alstolenine as the champion with a binding affinity of -7.25 kcal/mol  against the TRPV3 ion channel.  It is also non-toxic. Synergistic with conventional therapeutics : vis-à-vis psoriasis.

Conclusion :  Alstonia scholaris bark as whole supports use as ‘Functional Food’. Alstolenine posits as a good candidate for further ‘Drug Discovery’ related studies : vis-à-vis psoriasis.