Interaction between sensory dendrite and epithelial cells in Drosophila

  • Chee Wei Tee Advanced Molecular Biology Laboratory, School of Health Sciences, Universiti Sains Malaysia
  • Shaharum Shamsuddin Advanced Molecular Biology Laboratory, School of Health Sciences, Universiti Sains Malaysia

Abstract

Contact-mediated self-avoidance/repulsion restricts dendrite in a 2D space. Defect in dendrite-extracellular matrix (ECM) adhesion disrupts the confinement and results in self-crossings in 3D space. In this study, epithelial genes underlying dendrite-ECM affecting larval dendrite patterning were identified through genetic screen using mutants and RNAi knockdown. In-vitro and in-vivo assays were performed to characterize the epithelial gene function. To understand their mechanism, further in-depth study is required to elucidate their roles in coordinating sensory dendrite arborization.

 

 


Keywords: Dendrite; epithelial cells; Drosophila

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Published
2018-10-17
How to Cite
Tee, C. W., & Shamsuddin, S. (2018). Interaction between sensory dendrite and epithelial cells in Drosophila. Asian Journal of Medicine and Biomedicine, 35. Retrieved from https://journal.unisza.edu.my/ajmb/index.php/ajmb/article/view/174
Issue
Supplementary 3, 2018 (ACMBMB)
Section
Articles