Evaluation of DPPH Free Radical Scavenging, α-Glucosidase Inhibitory, and Antimicrobial Activities of Aquilaria malaccensis Leaf Extracts

Authors

  • Wan Ahmad Wan Nadilah Institute of Agricultural Production and Food Innovation (AGROPOLIS), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA.
  • Abdul Manaf Ali Faculty of Bioresources and Food Industry (FBIM), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA.
  • Wan Nur Amalina Wan Mamat Institute of Agricultural Production and Food Innovation (AGROPOLIS), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA.
  • Nor Hasima Mahmod Faculty of Bioresources and Food Industry (FBIM), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA

Keywords:

Aquilaria malaccensis, DPPH free radical scavenging, α-glucosidase inhibitory, antimicrobial, solvent polarity

Abstract

Herbs and medicinal plants are major ingredients in traditional or folk medicine for many countries of the world, including Malaysia. This study evaluated the potential of the leaf extract in different solvent polarities and drying methods of Aquilaria malaccensis, in scavenging free radicals and inhibiting the enzyme α-glucosidase as well as antimicrobial activities. Both methanol and ethanol extracts in oven dry method were efficient solvents to extract the antioxidant constituents of A. malaccensis. To analyze α-glucosidase inhibitory activity, the methanol extracts of A. malaccensis in air dry method exhibited the highest activity with an IC50 value of 196.31 μg/mL. In addition, for the antimicrobial activity, each extract was tested by a serial two-fold dilution method against selected Gram-positive bacteria and Gram-negative bacteria, and this suggested that hexane in oven dry method possessed the maximum antimicrobial activity against the gram-positive bacteria tested. It is suggested that the antioxidant and antidiabetic properties were exhibited most in a polar solvent (MEOH) whether in air dry or oven dry method with no significant difference. In contrary with antimicrobial which was efficient in a non-polar solvent (HEX) in oven dry method. These results indicate that A. malaccensis is a promising source as herbal medicine.

Author Biographies

  • Wan Ahmad Wan Nadilah, Institute of Agricultural Production and Food Innovation (AGROPOLIS), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA.

    Institute of Agricultural Production and Food Innovation (AGROPOLIS),
    Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut,
    Terengganu Darul Iman, MALAYSIA.

  • Abdul Manaf Ali, Faculty of Bioresources and Food Industry (FBIM), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA.

    Faculty of Bioresources and Food Industry (FBIM),
    Universiti Sultan Zainal Abidin (UniSZA),
    Besut Campus, 22200, Besut,
    Terengganu Darul Iman, MALAYSIA.

  • Wan Nur Amalina Wan Mamat, Institute of Agricultural Production and Food Innovation (AGROPOLIS), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA.

    Institute of Agricultural Production and Food Innovation (AGROPOLIS),
    Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut,
    Terengganu Darul Iman, MALAYSIA.

  • Nor Hasima Mahmod, Faculty of Bioresources and Food Industry (FBIM), Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Besut, Terengganu Darul Iman, MALAYSIA

    Faculty of Bioresources and Food Industry (FBIM),
    Universiti Sultan Zainal Abidin (UniSZA),
    Besut Campus, 22200, Besut,
    Terengganu Darul Iman, MALAYSIA

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Published

13-05-2019

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Articles

How to Cite

Evaluation of DPPH Free Radical Scavenging, α-Glucosidase Inhibitory, and Antimicrobial Activities of Aquilaria malaccensis Leaf Extracts. (2019). Journal Of Agrobiotechnology, 10(1). https://journal.unisza.edu.my/agrobiotechnology/index.php/agrobiotechnology/article/view/177